HCID 19028885, compound → HCID 19028782, compound

HRID 2256341Notes

Reaction equation

HRID 2256341 reaction equation
[CH:1]([NH:3][CH2:4][C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH2:7][CH2:8]I)=[O:2].[C:22]1(=[O:32])[NH:26][C:25](=[O:27])[C:24]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:23]12.[K]>CN(C=O)C>[CH:1]([NH:3][CH2:4][C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH2:7][CH2:8][N:26]1[C:25](=[O:27])[C:24]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:23]2[C:22]1=[O:32])=[O:2]

Participants

4

Reactant 2

HCID 19028885HCID 19028885, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 19028782HCID 19028782, compoundYield 70.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-formylamino-1-iodo-4,4-diphenylpentane (7 g) and potassium phthalimide (3.63 g) was stirred in DMF (40 ml) at room temperature for 3 hours. The reaction mixture was poured in ice-water and the syrup which separated out was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated to dryness. The residue was washed with isopropyl ether to provide the title compound (5.2 g) as colorless powder.

Workup

  1. customthe syrup which separated out
  2. extractionwas extracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated to dryness
  6. washThe residue was washed with isopropyl ether

Sources & evidence

ORD record
ord-524ad0dab1de4a85a4566bd86aa059d1
Source dataset
uspto-grants-1997_08
Patent number
US05654296

Reaction notes

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