Tributyl(5,6-dihydro-1,4-dioxin-2-yl)stannane → 2-Benzyl-5-(5,6-dihydro-[1,4]dioxin-2-yl)-2,3-Dihydro-1H-isoindole

HRID 225653Notes

Reaction equation

HRID 225653 reaction equation
[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](Br)[CH:14]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:23]1[O:24][CH2:25][CH2:26][O:27][CH:28]=1)CCC>>[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:23]3[O:24][CH2:25][CH2:26][O:27][CH:28]=3)[CH:14]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11100832Tributyl(5,6-dihydro-1,4-dioxin-2-yl)stannaneHCID 534165502-Benzyl-5-bromoisoindoline

Product 1

HCID 577532852-Benzyl-5-(5,6-dihydro-[1,4]dioxin-2-yl)-2,3-Dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A49(a) from 2-benzyl-5-bromo-2,3-dihydro-1H-isoindole (Example A62(a)) and tributyl-(5,6-dihydro-[1,4]dioxin-2-yl)-stannane. Light brown solid. MS (m/e): 294.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-6c91878463d6457ab35dc027b5d49f4c
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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