2,2,2-Trifluoroethanol → 5-(2,2,2-Trifluoro-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 225658Notes

Reaction equation

HRID 225658 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:18][C:19]([F:23])([F:22])[CH2:20][OH:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][CH2:20][C:19]([F:23])([F:22])[F:18])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577537125-(2,2,2-Trifluoro-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to Example A6(a) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 2,2,2-trifluoroethanol. Yellow solid. MS (m/e): 262.0 ([M+H−Me2C═CH2]+, 100%)

Sources & evidence

ORD record
ord-7beb875f1fed4951812665f4ce6fd21b
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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