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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225664Generated: October 29, 2026

Trifluoroacetic acid → 5-Chloro-6-(tetrahydro-furan-3-yl)-2,3-Dihydro-1H-isoindole trifluoroacetate

https://huagongshe.com/reaction/225664

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant5-Chloro-6-(tetrahydro-furan-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753320—
Product5-Chloro-6-(tetrahydro-furan-3-yl)-2,3-Dihydro-1H-isoindole trifluoroacetateHCID 68821451—

Reaction Steps

Prepared in analogy to Example A2(c) from 5-chloro-6-(tetrahydro-furan-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown oil. MS (m/e): 226.2 ([{37Cl}M+H]+, 33%), 224.2 ([{35Cl}M+H]+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-338350a8aec6407e9ceb39ab9a97e761
Source noteuspto-grants-2009_07