Trifluoroacetic acid → 5-Chloro-6-(tetrahydro-furan-3-yl)-2,3-Dihydro-1H-isoindole trifluoroacetate

HRID 225664Notes

Reaction equation

HRID 225664 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH:18]3[CH2:22][CH2:21][O:20][CH2:19]3)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[CH:18]1[CH2:22][CH2:21][O:20][CH2:19]1)[CH2:9][NH:8][CH2:16]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577533205-Chloro-6-(tetrahydro-furan-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688214515-Chloro-6-(tetrahydro-furan-3-yl)-2,3-Dihydro-1H-isoindole trifluoroacetate

Procedure

Prepared in analogy to Example A2(c) from 5-chloro-6-(tetrahydro-furan-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown oil. MS (m/e): 226.2 ([{37Cl}M+H]+, 33%), 224.2 ([{35Cl}M+H]+, 100%).

Sources & evidence

ORD record
ord-338350a8aec6407e9ceb39ab9a97e761
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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