Trifluoroacetic acid → HCID 68826808, compound

HRID 225668Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][C@@H:22]4[CH2:24][C@H:19]3[CH2:20][O:21]4)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[Cl:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[N:18]1[CH2:23][C@@H:22]3[CH2:24][C@H:19]1[CH2:20][O:21]3)[CH2:9][NH:8][CH2:16]2

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68822122HCID 68822122, compound

Product 1

HCID 68826808HCID 68826808, compound

Procedure

Prepared in analogy to Example A2(c) from 5-chloro-6-(1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown oil. MS (m/e): 253.1 ([{37Cl}M+H]+, 26%), 251.1 ([{35Cl}M+H]+, 100%).

Sources & evidence

ORD record: ord-71980529e877403c86fc950f511ba176
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

Loading…