Hydrochloric Acid → HCID 86606439, compound

HRID 2256692Notes

Reaction equation

HRID 2256692 reaction equation
[CH2:1]([NH:5][C:6](=[O:38])[C@H:7]([CH3:37])[CH2:8][C@H:9]([OH:36])[C@@H:10]([NH:28]C(OC(C)(C)C)=O)[CH2:11][C@@H:12]([CH:25]([CH3:27])[CH3:26])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[C:16]([OH:24])[CH:15]=1)[CH2:2][CH2:3][CH3:4].[ClH:39]>O1CCOCC1>[ClH:39].[CH2:1]([NH:5][C:6](=[O:38])[C@H:7]([CH3:37])[CH2:8][C@H:9]([OH:36])[C@@H:10]([NH2:28])[CH2:11][C@@H:12]([CH:25]([CH3:26])[CH3:27])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([CH3:22])([CH3:23])[CH3:21])=[C:16]([OH:24])[CH:15]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131719566HCID 131719566, compound

Product 1

HCID 86606439HCID 86606439, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

30 mg of N-tert-butoxycarbonyl-2(R)-methyl-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(3-hydroxy-4-tert-butyl-phenyl)-octanoic acid (N-butyl)amide are treated with 0.6 ml of 4N hydrochloric acid in dioxane analogously to Example 1 and the product is purified by means of FC (15 g of silica gel, dichloromethane/methanol=9:1). The title compound is obtained: Rf (dichloromethane/methanol=9:1)=0.17; Rt (I)=28.54 minutes; FAB-MS (M+H)+ =435.

Workup

  1. customthe product is purified by means of FC (15 g of silica gel, dichloromethane/methanol=9:1)

Sources & evidence

ORD record
ord-1f12a0e90e56429eb841bf5f849ce565
Source dataset
uspto-grants-1997_08
Patent number
US05654445

Reaction notes

Loading…