HRID2256737

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

反应SMILES：COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C[C@@H](C)C(=O)NCCCC(N)=O)C(C)C)ccc1OC

HCID54299838

未命名化合物

PRODUCTS

产物

反应SMILES：COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C)C(=O)NCCCC(N)=O)C(C)C)ccc1OC.Cl

HCID23626573

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

84 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(3-carbamoyl-propyl)]-amide are dissolved in 3 ml of 4N hydrochloric acid in dioxane at 0° C. and the mixture is stirred for 2 hours at 0° C. The reaction mixture is lyophilised. The title compound is obtained: Rf (dichloromethane/methanol=9:1)=0.04; HPLC Rt =9.44 minutes; HR FAB-MS (M+H)+ =510.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-d85dc7e2f45a4631ba6ffec4a3e153aa
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05654445
来源说明: uspto-grants-1997_08

反应SMILES

[C:1]([CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:43])[C@H:9]([CH3:42])[CH2:10][C@H:11]([OH:41])[C@@H:12]([NH:33]C(OC(C)(C)C)=O)[CH2:13][C@@H:14]([CH:30]([CH3:32])[CH3:31])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[CH:17]=1)(=[O:3])[NH2:2].[ClH:44]>O1CCOCC1>[ClH:44].[C:1]([CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:43])[C@H:9]([CH3:42])[CH2:10][C@H:11]([OH:41])[C@@H:12]([NH2:33])[CH2:13][C@@H:14]([CH:30]([CH3:32])[CH3:31])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[CH:17]=1)(=[O:3])[NH2:2]