4-Tributylstannyl-3,6-dihydro-2H-pyran → 2-Benzhydryl-5-(3,6-dihydro-2H-pyran-4-yl)-6-fluoro-2,3-dihydro-1H-isoindole

HRID 225674Notes

Reaction equation

HRID 225674 reaction equation
[CH:1]([N:14]1[CH2:22][C:21]2[C:16](=[CH:17][C:18](I)=[C:19]([F:23])[CH:20]=2)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:30]1[CH2:31][CH2:32][O:33][CH2:34][CH:35]=1)CCC>>[CH:1]([N:14]1[CH2:15][C:16]2[C:21](=[CH:20][C:19]([F:23])=[C:18]([C:30]3[CH2:35][CH2:34][O:33][CH2:32][CH:31]=3)[CH:17]=2)[CH2:22]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222522584-Tributylstannyl-3,6-dihydro-2H-pyranHCID 57753282HCID 57753282, compound

Product 1

HCID 577532392-Benzhydryl-5-(3,6-dihydro-2H-pyran-4-yl)-6-fluoro-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A49(a) from 2-benzhydryl-5-fluoro-6-iodo-2,3-dihydro-1H-isoindole and tributyl-(3,6-dihydro-2H-pyran-4-yl)-stannane. Yellow solid. MS (m/e): 386.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-f5c190cfadf04625a30962417b547de6
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

Loading…