Tetrahydro-4H-pyran-4-ol → HCID 57753714, compound

HRID 225676Notes

Reaction equation

HRID 225676 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:18]1[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:24][CH:21]3[CH2:22][CH2:23][O:18][CH2:19][CH2:20]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 57753714HCID 57753714, compound

Procedure

Prepared in analogy to Example A6(a) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and tetrahydro-4H-pyran-4-ol. White solid. MS (m/e): 264.1 ([M+H—Me2C═CH2]+, 100%)

Sources & evidence

ORD record
ord-e59d48c039aa49a8ac481e359cd99e14
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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