Methylamine → HCID 53805587, compound

HRID 2256761Notes

Reaction equation

HRID 2256761 reaction equation
C([O:3][C:4](=O)[CH2:5][C@@H:6]([NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[CH:7]([CH3:9])[CH3:8])C.[CH3:22][NH2:23]>>[CH3:22][NH:23][C:4](=[O:3])[CH2:5][C@@H:6]([NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[CH:7]([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 54226119HCID 54226119, compound

Product 1

HCID 53805587HCID 53805587, compound

Procedure

2.23 g of 3(R)-benzyloxycarbonylamino-4-methylpentanoic acid ethyl ester and 50 ml of 33% methylamine (in ethanol) are left to stand for 48 hours at room temperature. The reaction mixture is concentrated by evaporation and the residue is crystallised from ethyl acetate. The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.24; m.p. 190°-191° C.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customthe residue is crystallised from ethyl acetate

Sources & evidence

ORD record
ord-70c113455c51470bbd8ba45ed133aaee
Source dataset
uspto-grants-1997_08
Patent number
US05654445

Reaction notes

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