HRID2256767

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14882781

Ethyl 2-(aminomethyl)-2-ethylbutanoate

C9H19NO2

结构：COCCCOc1cc(C[C@@H](C[C@H]2[C@H](C[C@H](C(=O)O)C(C)C)OC(C)(C)N2C(=O)OC(C)(C)C)C(C)C)ccc1OC

HCID23625479

(αS,4S,5S)-3-[(1,1-Dimethylethoxy)carbonyl]-4-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-2,2-dimethyl-α-(1-methylethyl)-5-oxazolidinepropanoic acid

C33H55NO8

PRODUCTS

生成物

结构：CCC(CC)(CNC(=O)[C@@H](C[C@@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@H]1C[C@H](Cc1ccc(OC)c(OCCCOC)c1)C(C)C)C(C)C)C(=O)O

HCID22872378

未命名化合物

PROCEDURE

实验过程

The starting material is prepared analogously to Example 124 b) from 3-tert-butoxycarbonyl-5(S)-(2(S)-carboxy-3-methyl-butyl)-4(S)-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propyl}-2,2-dimethyl-1,3-oxazolidine (Example 124 c) and 3-amino-2,2-diethylpropionic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bae4e8a4c5e94a16b752038d73a592e6
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05654445
来源说明: uspto-grants-1997_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:12]([CH2:13][C@@H:14]([CH:30]([CH3:32])[CH3:31])[CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[CH:17]=2)[C@H:11]([CH2:33][C@H:34]([C:38](O)=[O:39])[CH:35]([CH3:37])[CH3:36])[O:10][C:9]1([CH3:42])[CH3:41])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O:45][C:46](=[O:54])[C:47]([CH2:52][CH3:53])([CH2:50][CH3:51])[CH2:48][NH2:49])C>>[C:1]([O:5][C:6]([N:8]1[C@@H:12]([CH2:13][C@@H:14]([CH:30]([CH3:32])[CH3:31])[CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[CH:17]=2)[C@H:11]([CH2:33][C@H:34]([C:38](=[O:39])[NH:49][CH2:48][C:47]([C:46]([OH:45])=[O:54])([CH2:50][CH3:51])[CH2:52][CH3:53])[CH:35]([CH3:36])[CH3:37])[O:10][C:9]1([CH3:41])[CH3:42])=[O:7])([CH3:4])([CH3:3])[CH3:2]