Ethyl 2-(aminomethyl)-2-ethylbutanoate → 3-Tert-butoxycarbonyl-5(S)-{2-[N-(2-carboxy-2,2-diethyl-ethyl)-carbamoyl]-2(S)-isopropyl-ethyl}-4(S)-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propyl}-2,2-dimethyl-1,3-oxazolidine

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(aminomethyl)-2-ethylbutanoate	HCID 14882781	—
Reactant	5-Oxazolidinepropanoic acid, 3-[(1,1-dimethylethoxy)carbonyl]-4-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-2,2-dimethyl-alpha-(1-methylethyl)-, (alphaS,4S,5S)-	HCID 23625479	—
Product	3-Tert-butoxycarbonyl-5(S)-{2-[N-(2-carboxy-2,2-diethyl-ethyl)-carbamoyl]-2(S)-isopropyl-ethyl}-4(S)-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propyl}-2,2-dimethyl-1,3-oxazolidine	HCID 22872378	—

Reaction Steps

The starting material is prepared analogously to Example 124 b) from 3-tert-butoxycarbonyl-5(S)-(2(S)-carboxy-3-methyl-butyl)-4(S)-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propyl}-2,2-dimethyl-1,3-oxazolidine (Example 124 c) and 3-amino-2,2-diethylpropionic acid ethyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05654445
Source dataset	uspto-grants-1997_08
ORD ID	ord-bae4e8a4c5e94a16b752038d73a592e6
Source note	uspto-grants-1997_08