Hydrochloric Acid → 2-Chloro-2-methyl-3-nitrosopentane
Reaction equation
[ClH:1].[N:2]([O:4]CCC(C)C)=O.[CH3:10][C:11](=[CH:13][CH2:14][CH3:15])[CH3:12]>>[Cl:1][C:11]([CH3:12])([CH3:10])[CH:13]([N:2]=[O:4])[CH2:14][CH3:15]Participants
4
Conditions
- Temperature
- 5 °C
Procedure
Concentrated HCl (9.0 mL, 0.11 mol) was added to a cooled (0°-5° C.) solution of isoamyl nitrite (14.8 g, 0.1 mol) and 2-methyl-2-pentene (8.4 g, 0.1 mol). The temperature was. maintained below 5° C. during the addition and the reaction mixture was stirred at 5° C. for an additional 30 min. The product was filtered and washed with a cold (-20° C.) 1:1 mixture of petroleum ether. The solid was further washed with petroleum ether to afford a white solid.
Workup
- temperaturemaintained below 5° C. during the addition
- filtrationThe product was filtered
- washwashed with a cold (-20° C.) 1:1 mixture of petroleum ether
- washThe solid was further washed with petroleum ether
- customto afford a white solid
Sources & evidence
- ORD record
- ord-1006aec93e534246a55dd93001ac0d9f
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05656254
Reaction notes
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