Phosphorus pentachloride → 4-Bromobenzylsulfonyl chloride

Temperature

80 °C

The 4-bromobenzylsulfonic acid, sodium salt (12.9 g, 43.6 mmol) was combined without further purification with phosphorus pentachloride (10.8 g, 52 mmol) to form an intimate mixture. The mixture was heated to 80° C. under a nitrogen atmosphere and became homogeneous after about 30 minutes. The reaction mixture was maintained at this temperature for about 5 hours. It was then cooled, diluted with diethyl ether and added to a large volume of ice. The ether layer was separated, washed with water and a saturated brine solution and dried over magnesium sulfate. The solvent was then removed with a rotary evaporator to obtain 4-bromobenzylsulfonyl chloride (13.3 g), a small quantity of which was recrystallized from hexane for analysis. The m.p. was about 114° C. to about 116° C. and the 1H NMR spectrum confirmed that the reaction product was 4-bromobenzylsulfonylchloride. The theoretical elemental analysis for bromobenzylsulfonylchloride is: C, 31.19%; H, 2.24%; S, 11.89% and the actual analysis was: C, 31.23%; H, 2.41%; S, 11.73%.

1. customto form an intimate mixture
2. temperatureThe reaction mixture was maintained at this temperature for about 5 hours
3. temperatureIt was then cooled
4. additionadded to a large volume of ice
5. customThe ether layer was separated
6. washwashed with water
7. dry with materiala saturated brine solution and dried over magnesium sulfate
8. customThe solvent was then removed with a rotary evaporator

ORD record

ord-3e01abf8d86441208c81ffda6b853d69

Source dataset

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05656412