Cyclopropanemethanol → 5-Cyclopropylmethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 225681Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:18]1([CH2:21][OH:22])[CH2:20][CH2:19]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:22][CH2:21][CH:18]3[CH2:20][CH2:19]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 75644Cyclopropanemethanol

HCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577532755-Cyclopropylmethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Procedure

Prepared in analogy to Example A6(a) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and cyclopropylmethanol. Off-white solid. MS (m/e): 234.1 ([M+H-Me2C═CH2]+, 100%)

Sources & evidence

ORD record: ord-69df966797aa4ee9bc4a785468f48e19
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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