Trifluoroacetic acid → 5-Cyclopropylmethoxy-2,3-dihydro-1H-isoindole trifluoroacetate

HRID 225682Notes

Reaction equation

HRID 225682 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[CH:19]1([CH2:18][O:17][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577532755-Cyclopropylmethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688255995-Cyclopropylmethoxy-2,3-dihydro-1H-isoindole trifluoroacetate

Procedure

Prepared in analogy to Example A2(c) from 5-cyclopropylmethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. MS (m/e): 190.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-16a688ec591742b2be8f95f1e7a03a81
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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