HCID 57259964, compound → HCID 67641539, compound

HRID 2256830Notes

Reaction equation

HRID 2256830 reaction equation
Cl.[NH2:2][C@@H:3]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:4]([N:6]([CH3:8])[CH3:7])=[O:5].[CH2:13]([O:20][C:21](=[O:31])[C@@H:22]([O:27][C:28](Cl)=[O:29])[CH2:23][CH:24]([CH3:26])[CH3:25])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(OCC)(=O)C>[CH2:13]([O:20][C:21](=[O:31])[C@@H:22]([O:27][C:28](=[O:29])[NH:2][C@H:3]([C:4](=[O:5])[N:6]([CH3:8])[CH3:7])[C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:23][CH:24]([CH3:25])[CH3:26])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 57259964HCID 57259964, compoundHCID 86751143HCID 86751143, compound

Product 1

HCID 67641539HCID 67641539, compoundYield 85.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(2S)-2-Amino-3,3-dimethyl-N,N-dimethylbutyramide hydrochloride (0.25 g), (2S)-2-chlorocarbonyloxy-4-methylvaleric acid benzyl ester (0.36 g) and TEA (0.31 g) were reacted in ethyl acetate (10 ml) in a similar manner to that of Example 4-1) to give (2S)-2-[N-[(1S)-2,2-dimethyl-1-(N,N-dimethylcarbamoyl)propyl]-carbamoyloxy]-4-methylvaleric acid benzyl ester (0.44 g).

Sources & evidence

ORD record
ord-b6fb327a909141bb954485d25ac62749
Source dataset
uspto-grants-1997_08
Patent number
US05656604

Reaction notes

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