反应详情

温度

20 °C

A solution of methylmagnesium iodide (2.5 mmol) in dry diethyl ether (2.5 ml) [prepared at 20° C. from magnesium (60 mg; 2.5 mmol) and methyl iodide (0.16 ml; 2.5 mmol)] was cooled to 0° C. Copper(I) iodide (46 mg; 0.24 mmol) was added. After 5 min. at 0° C., a solution of the 15-ethyl-Δ15 -17-ketone (7) (150 mg; 0.48 mmol) in dry tetrahydrofuran (3 ml) was added. The mixture was stirred at 20° C. for 15 min. Saturated aqueous ammonium chloride and aqueous ammonia were added and the residue upon work-up (ethyl acetate) (150 mg; 96%) was crystallized from chloroform to give the 5α-ethyl-3-methoxy-15β-methylestra-1,3,5(10) -trien-17-one (8) (127 mg; 81%).; m.p. 110°-113° C. (from chloroform-methanol); [α]D +90° (c 1.0); υmax 1724 cm-1 (CO); δH 0.89 (3H, t, J 7.4 Hz, 15α-CH2CH3), 1.12 (3H, s, 13β-Me), 1.25 (3H, s, 15β-Me), 1.36 and 1.76 (each 2H, degen. dq, J 14.8 and 3×7.4 Hz, 15α-CH2CH3), 2.18 and 2.44 (each 1H, d, J 19.4 Hz, 16α- and 16β-H), 2.88 (2H, m, 6-H2), 3.77 (3H, s, 3-OMe), 6.62 (1H, d, J 2.9 Hz, 4-H), 6.71 (1H, dd, J 8.6 and 2.9 Hz, 2-H), and 7.20 (1H, d, J 8.6 Hz, 1-H); δC 9.4 (C-152), 18.2 (C-18), 21.8 (C-151), 26.1 (C-11), 28.3 (C-7), 29.9 (C-6), 34.2 (C-12), 37.5 (C-8), 38.1 (15β-Me), 38.9 (C-15), 44.9 (C-9), 49.8 (C-16), 50.0 (C-13), 55.2 (3-OMe), 56.6 (C-14), 111.6 (C-2), 113.6 (C-4), 126.5 (C-1), 132.2 (C-10), 137.4 (C-5), 157.6 (C-3), and 220.4 (C-17) (Found: C, 81.2; H, 9.5%; M+, 326. C22H30O2 requires C, 80.9; 9.3%; M, 326).

1. customthe residue upon work-up (ethyl acetate) (150 mg; 96%) was crystallized from chloroform