Tetrahydro-4H-pyran-4-ol → HCID 57753621, compound

HRID 225692Notes

Reaction equation

HRID 225692 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12](I)=[C:13]([F:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:19]1[CH2:24][CH2:23][CH:22]([OH:25])[CH2:21][CH2:20]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:25][CH:22]3[CH2:23][CH2:24][O:19][CH2:20][CH2:21]3)=[C:13]([F:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 57753705HCID 57753705, compound

Product 1

HCID 57753621HCID 57753621, compound

Procedure

Prepared in analogy to Example A6(a) from 5-fluoro-6-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A84(f)) and tetrahydro-4H-pyran-4-ol. Yellow solid. MS (m/e): 282.3 ([M+H-Me2C═CH2]+, 100%).

Sources & evidence

ORD record
ord-b0436ee7918f457fa9f688de55cfcb50
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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