Trifluoroacetic acid → HCID 68826269, compound

HRID 225693Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:13]([F:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[F:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:18][CH:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)[CH2:9][NH:8][CH2:16]2

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57753621HCID 57753621, compound

Product 1

HCID 68826269HCID 68826269, compound

Procedure

Prepared in analogy to Example A2(c) from 5-fluoro-6-(tetrahydro-pyran-4-yloxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. 238.1 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-71dc8fc78ea443de9994c9a61aaa764d
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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