2-Chloro-5-(methylsulphonyl)benzoic acid → 2-Isobutoxy-5-methanesulfonyl-benzoic acid

HRID 225702Notes

Reaction equation

HRID 225702 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C(O)C(C)C>[CH2:4]([O:5][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[CH:3]([CH3:7])[CH3:2]

Participants

3

Reactant 1

HCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

Product 1

HCID 235031102-Isobutoxy-5-methanesulfonyl-benzoic acid

Reagents, catalysts & solvents 1

HCID 6560IsobutanolSolvent

Procedure

Prepared in analogy to Example B1(b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example B1(a)) and isobutanol. The crude material was purified by flash chromatography to yield the title compound as a white solid. MS (m/e): 271.1 ([M−H]−, 100%).

Workup

  1. customThe crude material was purified by flash chromatography

Sources & evidence

ORD record
ord-acaff5c22ef243018e0521efda93ef38
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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