Hydrogen Peroxide → HCID 21830878, compound

HRID 2257050Notes

Reaction equation

HRID 2257050 reaction equation
[OH2:1].[OH-].[K+].OO.[C:6]([N:10]1[C:14]([NH2:15])=[C:13]([C:16]#[N:17])[C:12]([CH3:18])=[N:11]1)([CH3:9])([CH3:8])[CH3:7]>C(O)C>[C:6]([N:10]1[C:14]([NH2:15])=[C:13]([C:16]([NH2:17])=[O:1])[C:12]([CH3:18])=[N:11]1)([CH3:9])([CH3:8])[CH3:7]

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14797Potassium HydroxideHCID 899884HCID 899884, compound

Product 1

HCID 21830878HCID 21830878, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of water (200 mL), ethanol (120 mL) and KOH (37 g, 0.56 mol) at 0° C. was added 30% H2O2 (89.1 g, 0.786 mol), followed by 1-tert-butyl-3-methyl-5-amino-1H-pyrazole-4-carbonitrile (20.0 g, 0.112 mol). The reaction mixture was stirred for 4 hours and the product was collected by filtration, washed with water and dried to afford 20.64 g (94%) of 1-tert-butyl-3-methyl-5-amino-1H-pyrazole-4-carboxamide, as white needles, m.p. 195°-196° C.

Workup

  1. filtrationthe product was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-c413c561b7ab4dec98b42aafecaa00e9
Source dataset
uspto-grants-1997_08
Patent number
US05656629

Reaction notes

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