Lithium Hydroxide → 5-Ethanesulfonyl-2-fluoro-benzoic acid

HRID 225722Notes

Reaction equation

C([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([S:11]([CH2:14][CH3:15])(=[O:13])=[O:12])[CH:8]=[CH:7][C:6]=1[F:16])C.[OH-].[Li+]>>[CH2:14]([S:11]([C:9]1[CH:8]=[CH:7][C:6]([F:16])=[C:5]([CH:10]=1)[C:4]([OH:17])=[O:3])(=[O:12])=[O:13])[CH3:15]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58863356HCID 58863356, compound

Product 1

HCID 211002995-Ethanesulfonyl-2-fluoro-benzoic acid

Procedure

Prepared in analogy to Example B3(c) from 5-Ethanesulfonyl-2-fluoro-benzoic acid ethyl ester using lithium hydroxide instead of sodium hydroxide. White solid. MS (m/e): 232.1 (M+, 100%).

Sources & evidence

ORD record: ord-0d2ac2f8fcaa46d6bb8609d60567099d
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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