1,1,1-Trifluorobutan-2-ol → 5-Methanesulfonyl-2-(1-trifluoromethyl-propoxy)-benzoic acid

HRID 225724Notes

Reaction equation

HRID 225724 reaction equation
F[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:15][C:16]([F:22])([F:21])[CH:17]([OH:20])[CH2:18][CH3:19]>>[CH3:14][S:11]([C:8]1[CH:9]=[CH:10][C:2]([O:20][CH:17]([C:16]([F:22])([F:21])[F:15])[CH2:18][CH3:19])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 113324711,1,1-Trifluorobutan-2-olHCID 224675662-Fluoro-5-methanesulfonyl-benzoic acid

Product 1

HCID 211003025-Methanesulfonyl-2-(1-trifluoromethyl-propoxy)-benzoic acid

Procedure

Prepared in analogy to Example B4(c) from 2-Fluoro-5-methanesulfonyl-benzoic acid (example B4(b)) and rac-1,1,1-Trifluoro-butan-2-ol (CAS: 431-36-7). White solid. MS (m/e): 325.0 ([M−H], 100%).

Sources & evidence

ORD record
ord-d94fceeda7da494e95df3e4005a99937
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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