Hydrochloric Acid → HCID 18915088, compound

HRID 2257294Notes

Reaction equation

HRID 2257294 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:13]>O1CCOCC1>[ClH:13].[ClH:13].[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholine

Product 1

HCID 18915088HCID 18915088, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 260 mg of 3-(pyrrolidin-1-ylmethyl)thiomorpholine and 5 ml of 1,4-dioxane was treated with 150 μl of 4N 1,4-dioxane solution of hydrogen chloride. The solvent was evaporated under reduced pressure to yield 354 mg (98%) of 3-(pyrrolidin-1-ylmethyl)thiomorpholine dihydrochloride, melting at 218°-220° C.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-ef9afd6db7db4dc5bce4bcfb6e25b049
Source dataset
uspto-grants-1997_08
Patent number
US05656758

Reaction notes

Loading…