2-Chloro-6,7-dihydro-5H-pyrrolo[3,4-B]pyridine → (2-Chloro-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

HRID 225740Notes

Reaction equation

HRID 225740 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[CH2:8][NH:9][CH2:10][C:5]2=[CH:4][CH:3]=1.[CH3:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([O:24][C@@H:25]([CH3:30])[C:26]([F:29])([F:28])[F:27])=[C:19]([CH:23]=1)[C:20](O)=[O:21])(=[O:14])=[O:13]>>[Cl:1][C:2]1[N:7]=[C:6]2[CH2:8][N:9]([C:20]([C:19]3[CH:23]=[C:15]([S:12]([CH3:11])(=[O:13])=[O:14])[CH:16]=[CH:17][C:18]=3[O:24][C@@H:25]([CH3:30])[C:26]([F:28])([F:29])[F:27])=[O:21])[CH2:10][C:5]2=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 113671312-Chloro-6,7-dihydro-5H-pyrrolo[3,4-B]pyridineHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 57753234(2-Chloro-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

Procedure

Prepared in analogy to Example 1 from 2-chloro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (Example A8(b)) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example B3). Yellow foam. MS (m/e): 451.0 ({37Cl}[M+H]+, 41%), 449.2 ({35Cl}[M+H]+, 100%).

Sources & evidence

ORD record
ord-5fcb25e7d9a1422684fa4429f5633449
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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