2-Chloro-6,7-dihydro-5H-pyrrolo[3,4-B]pyridine → (2-Chloro-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-6,7-dihydro-5H-pyrrolo[3,4-B]pyridine	HCID 11367131	—
Reactant	(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid	HCID 58863351	—
Product	(2-Chloro-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone	HCID 57753234	—

Reaction Steps

Prepared in analogy to Example 1 from 2-chloro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (Example A8(b)) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example B3). Yellow foam. MS (m/e): 451.0 ({37Cl}[M+H]+, 41%), 449.2 ({35Cl}[M+H]+, 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07557114B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-5fcb25e7d9a1422684fa4429f5633449
Source note	uspto-grants-2009_07