HCID 87596239, compound → HCID 87596248, compound

HRID 225780Notes

Reaction equation

C[O:2][C:3](=[O:37])[CH:4]([NH:25][C:26]1[C:29]2([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:28](=[O:35])[C:27]=1[Cl:36])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:17]1[CH:22]=[C:21]([Cl:23])[N:20]=[C:19]([Cl:24])[CH:18]=1)=[O:16])[CH2:10][CH2:9]2.ClC1C=NC=C(Cl)C=1C(N1C2C(=CC(CC(NC3C4(CCCCC4)C(=O)C=3)C(O)=O)=CC=2)CC1)=O>>[Cl:36][C:27]1[C:28](=[O:35])[C:29]2([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:26]=1[NH:25][CH:4]([CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:17]1[CH:22]=[C:21]([Cl:23])[N:20]=[C:19]([Cl:24])[CH:18]=1)=[O:16])[CH2:10][CH2:9]2)[C:3]([OH:37])=[O:2]

Participants

Reactant 2

HCID 87596239HCID 87596239, compound

HCID 87596574HCID 87596574, compound

Product 1

HCID 87596248HCID 87596248, compound

Procedure

The title compound was prepared from the compound of Example 11 in a similar manner to the compound of Example 2 as a white lyophilised powder (64%). δH NMR (d6 DMSO) 8.80 (1H, d, J 9.6 Hz), 7.98 (1H, d, J 8.2 Hz), 7.85 (2H, s), 7.14 (2H, m), 4.57 (1H, m), 3.96 (2H, t, J 8.2 Hz), 3.21 (1H, dd, J 13.6 and 3.7 Hz), 3.04 (2H, m), 2.92 (1H, dd, J 13.6 and 10.6 Hz), 1.44 (10H, br m), m/z (ES+, 70 eV) 550 (M+H)+.

Sources & evidence

ORD record: ord-cf725c177b044d4d98f154188ae60e25
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557130B2

Reaction notes

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