HCID 87596154, compound → HCID 87596536, compound

HRID 225784Notes

Reaction equation

[Cl:1][C:2]1[C:5](=[O:6])[C:4]([CH3:8])([CH3:7])[C:3]=1[NH:9][CH:10]([CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25](=[O:34])[C:26]1[C:31]([Cl:32])=[CH:30][N:29]=[CH:28][C:27]=1[Cl:33])[CH2:20][CH2:19]2)[C:11]([O:13]C)=[O:12].ClC1C=NC=C(Cl)C=1C(N1C2C(=CC(CC(NC3C4(CCCCC4)C(=O)C=3)C(O)=O)=CC=2)CC1)=O>>[Cl:1][C:2]1[C:5](=[O:6])[C:4]([CH3:8])([CH3:7])[C:3]=1[NH:9][CH:10]([CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25](=[O:34])[C:26]1[C:27]([Cl:33])=[CH:28][N:29]=[CH:30][C:31]=1[Cl:32])[CH2:20][CH2:19]2)[C:11]([OH:13])=[O:12]

Participants

Reactant 2

HCID 87596154HCID 87596154, compound

HCID 87596239HCID 87596239, compound

Product 1

HCID 87596536HCID 87596536, compound

Procedure

The title compound was prepared from the compound of Example 30 in a similar manner to the compound of Example 2 as a white solid (78 mg, 61%). δH NMR (d6 DMSO) 8.82 (2H, s), 8.02 (0.88H, d) & 5.73 (0.12H, d), 8.74 (0.12H, d) & 7.19 (0.88H, s), 7.13 (0.88H, d) & 6.80 (0.12H, t), 4.56 (1H, br m), 3.74 (2H, t, J 8.1 Hz), 3.11 (4H, m), 0.82 (3H, s), 0.80 (3H, s). m/z (ES+, 70V) 508 (MH+).

Sources & evidence

ORD record: ord-fb934af7076b4edbabb0007a94381462
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557130B2

Reaction notes

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