Acetic Acid → HCID 22449479, compound

HRID 2257843Notes

Reaction equation

HRID 2257843 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8](Cl)=[C:9]2[C:14]=1[C:13](=O)[C:12](=CO)[CH2:11][CH2:10]2)(=[O:3])[CH3:2].[C:19](O)(=O)C.[ClH:23].[NH2:24][OH:25]>O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([Cl:23])=[C:9]2[C:14]=1[C:13]1[CH:19]=[N:24][O:25][C:12]=1[CH2:11][CH2:10]2)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 70156897HCID 70156897, compound

Product 1

HCID 22449479HCID 22449479, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

1.29 gm of the compound prepared in (1) above was dissolved into 30 ml of acetic acid. After the addition of 339 mg of hydroxylamine hydrochloride, the mixture was heated for 10 minutes at 120° C. while stirring. After cooling, water was added to collect the precipitate by filtration. The precipitate was washed with water and hexane to obtain 1.1 gm of the title compound.

Workup

  1. temperatureAfter cooling
  2. customto collect the precipitate
  3. filtrationby filtration
  4. washThe precipitate was washed with water and hexane

Sources & evidence

ORD record
ord-a11f1dec819b44eab958c3208cca683d
Source dataset
uspto-grants-1997_08
Patent number
US05658920

Reaction notes

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