HCID 68843691, compound → HCID 68846184, compound

HRID 225785Notes

Reaction equation

[Cl:1][C:2]1[C:7](=[O:8])[CH2:6][CH:5]([CH2:9][CH2:10][CH3:11])[CH2:4][C:3]=1[NH:12][CH:13]([CH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[N:24]([C:28](=[O:37])[C:29]1[C:34]([Cl:35])=[CH:33][N:32]=[CH:31][C:30]=1[Cl:36])[CH2:23][CH2:22]2)[C:14]([O:16]C)=[O:15].ClC1C=NC=C(Cl)C=1C(N1C2C(=CC(CC(NC3C4(CCCCC4)C(=O)C=3)C(O)=O)=CC=2)CC1)=O>>[Cl:1][C:2]1[C:7](=[O:8])[CH2:6][CH:5]([CH2:9][CH2:10][CH3:11])[CH2:4][C:3]=1[NH:12][CH:13]([CH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[N:24]([C:28](=[O:37])[C:29]1[C:30]([Cl:36])=[CH:31][N:32]=[CH:33][C:34]=1[Cl:35])[CH2:23][CH2:22]2)[C:14]([OH:16])=[O:15]

Participants

Reactant 2

HCID 68843691HCID 68843691, compound

HCID 87596239HCID 87596239, compound

Product 1

HCID 68846184HCID 68846184, compound

Procedure

The title compound was prepared from the compound of Example 34 in a similar manner to the compound of Example 2 as a white solid (114.7 mg, 74.5%). δH NMR (d6 DMSO) 8.82 (2H, s), 8.03 (0.86H, d) & 5.74 (0.14H, d), 8.97 (0.15H, d) & 7.20 (2H, m), 7.15 (0.86H, d) & 6.80 (0.14H, d), 4.62 (1H, dd), 3.76 (2H, t, J 7.3 Hz), 3.21 (1H, dd), 3.13 (2H, t), 3.02 (1H, dd), 1.23-0.76 (8H, m), 1.04 (3H, s). m/z (ES+, 70V) 550 (MH+).

Sources & evidence

ORD record: ord-a1e23e55d1a5490699544e5d4bddb666
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557130B2

Reaction notes

Loading…