Ethanol → HCID 22923687, compound

HRID 2257898Notes

Reaction equation

HRID 2257898 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2.[S:18]([O-:21])([O-:20])=[O:19].[Na+].[Na+].C(O)C>O>[OH:21][S:18]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2)(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 702EthanolHCID 24437Sodium SulfiteHCID 22923693HCID 22923693, compound

Product 1

HCID 22923687HCID 22923687, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 53.3 g of 6-(4-chlorobutoxy)-carbostyril and 32 g of sodium sulfite dissolved in 500 ml of water and 200 ml of ethanol was refluxed for 1 day. The solution was allowed to cool and stand for 3 days and then filtered. The filtrate was made acidic with diluted hydrochloric acid. The solvent was removed by distillation. To the resulting residue was added water, and the precipitate was collected by filtration to obtain 47.5 g of 6-(4-hydroxysulfonylbutoxy)carbostyril as a white powder.

Workup

  1. temperatureto cool
  2. filtrationfiltered
  3. customThe solvent was removed by distillation
  4. additionTo the resulting residue was added water
  5. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-0439f71fb40240fa958503fa348143c5
Source dataset
uspto-grants-1997_08
Patent number
US05658926

Reaction notes

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