HCID 178487323, compound → HCID 178487324, compound

HRID 2257964Notes

Reaction equation

HRID 2257964 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]2[C:6]([C:7]([C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)=[CH:8][CH2:9]2)=[CH:5][CH:4]=1>CO.[Pd]>[CH3:13][O:12][C:11]1[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[C:6]2[C:10]=1[CH2:9][CH2:8][CH:7]2[C:14]1[N:15]=[CH:16][NH:17][CH:18]=1

Participants

4

Reactant 1

HCID 178487323HCID 178487323, compound

Product 1

HCID 178487324HCID 178487324, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.3 g (0.0095 mole) of 4-(6,7-dimethoxy-1H-inden-3-yl)-1H-imidazole prepared in Example 2.5.a in 200 ml of methanol are hydrogenated under a hydrogen pressure of 2 kg at 40° C., in the presence of palladium on carbon (Pd 10%). At the end of the reaction, the catalyst is filtered off and the methanol distilled. The residue is crystallized from ethyl acetate and 4-(2,3-dihydro-4,5-dimethoxy-1H-inden-1-yl)-1H-imidazole is obtained.

Workup

  1. customat 40° C.
  2. customAt the end of the reaction
  3. filtrationthe catalyst is filtered off
  4. distillationthe methanol distilled
  5. customThe residue is crystallized from ethyl acetate

Sources & evidence

ORD record
ord-e6a51e3cc72c490ca0685476cdf3955a
Source dataset
uspto-grants-1997_08
Patent number
US05658938

Reaction notes

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