HCID 67725500, compound → HCID 67725509, compound

HRID 2257994Notes

Reaction equation

HRID 2257994 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([CH2:9][CH2:10][C:11]([C:23]([O:25][CH2:26][CH3:27])=[O:24])([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:12][C:13]([O:15]CC)=[O:14])=[CH:7][CH:6]=1>Cl>[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][C:11]([C:23]([O:25][CH2:26][CH3:27])=[O:24])([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:12][C:13]([OH:15])=[O:14])=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 67725500HCID 67725500, compound

Product 1

HCID 67725509HCID 67725509, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

11.34 g of ethyl 4-[4-(aminoiminomethyl)benzyl]-3,3-bisethoxycarbonylbutyrate hydrochloride are stirred in 250 ml of 6N HCl at 40° C. for 1 h and at 80° C. for 2 h. The mixture is then allowed to stand overnight at room temperature and is concentrated to dryness in vacuo. The residue is taken up in a little water and freeze-dried.

Workup

  1. concentrationis concentrated to dryness in vacuo
  2. customfreeze-dried

Sources & evidence

ORD record
ord-051800d0e30c4cda8685a579cb0abe20
Source dataset
uspto-grants-1997_08
Patent number
US05658935

Reaction notes

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