Water → HCID 22923950, compound

HRID 2258002Notes

Reaction equation

HRID 2258002 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:11][C:10](=[O:12])[N:9]([CH2:13][C:14]([OH:16])=[O:15])[C:8]2=[O:17])=[CH:3][CH:2]=1.[H][H].O>C(O)(=O)C.[Rh]>[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[CH2:11][C:10](=[O:12])[N:9]([CH2:13][C:14]([OH:16])=[O:15])[C:8]2=[O:17])[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 962WaterHCID 22923962HCID 22923962, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22923950HCID 22923950, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 176Acetic AcidSolvent

Procedure

2.8 g of [3-(4-pyridyl)-2,5-dioxopyrrolidin-1-yl]acetic acid are suspended in 160 ml of acetic acid and hydrogenated in an autoclave at 100° C. and a hydrogen pressure of 150 bar for 24 h using 100 mg of 5% rhodium on carbon as a catalyst. The catalyst is then filtered off and the filtrate is concentrated to dryness in vacuo. The product thus obtained is taken up in a little water and freeze-dried.

Workup

  1. customhydrogenated in an autoclave at 100° C.
  2. filtrationThe catalyst is then filtered off
  3. concentrationthe filtrate is concentrated to dryness in vacuo
  4. customThe product thus obtained
  5. customfreeze-dried

Sources & evidence

ORD record
ord-b5f3375cb1fc4a99920072a91db32b17
Source dataset
uspto-grants-1997_08
Patent number
US05658935

Reaction notes

Loading…