2,2,2-Trifluoroethanol → Methyl 2,2,2-trifluoroethyl carbonate

Temperature

100 °C

In a flask (3-liter volume) equipped with 10 distillation columns, 2,2,2-trifluoroethanol (790 g, 7.9 ml), dimethyl carbonate (2140 g, 23.7 mol) and a 28% sodium methoxide/methanol solution (15.3 g) were charged. The flask was heated to 100° C. to allow the starting materials to react for 30 hours while removing the methanol from the distillation columns by evaporation. After allowing the mixture to cool to room temperature, an aqueous solution of ammonium chloride was added to the mixture and the mixture was shaken to remove the sodium methoxide. The organic layer was washed with water, dried and distilled to give methyl 2,2,2-trifluoroethyl carbonate as a colorless liquid (410 g, yield 33%). The chemical structure of the produced compound was determined based on the IR and NMR absorbance spectra shown in FIG. 3 and FIG. 4 respectively and the mass spectrometry spectrum (M/e=158).

1. customto react for 30 hours
2. customwhile removing the methanol
3. distillationfrom the distillation columns
4. customby evaporation
5. temperatureto cool to room temperature
6. additionan aqueous solution of ammonium chloride was added to the mixture
7. customto remove the sodium methoxide
8. washThe organic layer was washed with water
9. customdried
10. distillationdistilled

ORD record

ord-a53fc4f8f3b04d569b03142cb164f2d8

Source dataset

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05659062