2-Bromopyridine → tert-Butyl 4-(methyl(pyridin-2-yl)amino)piperidine-1-carboxylate

Temperatur

130 °C

A mixture of tert-butyl 4-(methylamino)piperidine-1-carboxylate (WO 03/089412, p22), (2 g, 9.33 mmol), 2-bromopyridine (1.35 mL, 13.99 mmol) and N,N-diisopropylethylamine (2.5 mL, 13.99 mmol) was heated at 130° C. for 3 hours. Potassium carbonate (2 g, 14 mmol) was added and the reaction mixture was heated at 130° C. for a further 8 hours. 2-Bromopyridine (1 mL, 10.36 mmol) was then added to the mixture and heating continued at 130° C. for 36 hours. The reaction mixture was then cooled and partitioned between ethyl acetate (30 mL) and water (15 mL). The organic layer was separated and extracted with saturated citric acid solution (2×15 mL), and the combined aqueous solution was basified with sodium hydrogen carbonate and extracted with dichloromethane (2×30 mL). The combined organic solution was dried over magnesium sulfate, concentrated in vacuo and the residue was purified by column chromatography on silica gel, eluting with ethyl acetate:pentane, 0:100 to 50:50, to afford the title compound in 24% yield, 646 mg. 1H NMR(CDCl3, 400 MHz) δ: 1.45(s, 9H), 1.55-1.70(m, 4H), 2.78-2.90(m, 5H), 4.10-4.30(m, 2H), 4.65-4.80(m, 1H), 6.45-6.55(m, 2H), 7.40-7.45(m, 1H), 8.10-8.15(m, 1H); LRMS APCI m/z 292 [M+H]+

1. temperaturethe reaction mixture was heated at 130° C. for a further 8 hours
2. temperatureheating
3. temperatureThe reaction mixture was then cooled
4. custompartitioned between ethyl acetate (30 mL) and water (15 mL)
5. customThe organic layer was separated
6. extractionextracted with saturated citric acid solution (2×15 mL)
7. extractionextracted with dichloromethane (2×30 mL)
8. dry with materialThe combined organic solution was dried over magnesium sulfate
9. concentrationconcentrated in vacuo
10. customthe residue was purified by column chromatography on silica gel
11. washeluting with ethyl acetate

ORD-Eintrag

ord-6086858506714ba3b6d6bd4919e503d2

Quelldatensatz

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07557131B2