2,2,3,3,3-Pentafluoropropanol → Methyl 2,2,3,3,3-pentafluoropropyl carbonate

HRID 2258151Notes

Reaction equation

HRID 2258151 reaction equation
C([O-])([O-])=O.[K+].[K+].C[O-].[Na+].CO.[F:12][C:13]([F:20])([C:16]([F:19])([F:18])[F:17])[CH2:14][OH:15].[C:21](=O)([O:24]C)[O:22][CH3:23]>>[C:21](=[O:24])([O:15][CH2:14][C:13]([F:20])([F:12])[C:16]([F:19])([F:18])[F:17])[O:22][CH3:23]

Participants

5

Reactant 4

HCID 98722,2,3,3,3-PentafluoropropanolHCID 11430Potassium CarbonateHCID 12021Dimethyl CarbonateHCID 23694274Sodium methanolate methanol

Product 1

HCID 18183634Methyl 2,2,3,3,3-pentafluoropropyl carbonateYield 55%

Procedure

Methyl 2,2,3,3,3-Pentafluoropropyl carbonate was prepared by the same manner as the example 4 except that K2CO3 (0.046 g) was used as a catalyst in stead of a 284 sodium methoxide/methanol solution (1.3 g). After 2,2,3,3,3-pentafluoropropanol and dimethyl carbonate were allowed to react, the mixture thereof was passed through a column filled with silicagel (8 g) in order to remove K2CO3, and was distilled to give methyl 2,2,3,3,3-pentafluoropropyl carbonate as a colorless liquid (yield 55%).

Workup

  1. customto react
  2. additionfilled with silicagel (8 g) in order
  3. customto remove K2CO3
  4. distillationwas distilled

Sources & evidence

ORD record
ord-a7de5c5da8c6434fadb10b84a71319ee
Source dataset
uspto-grants-1997_08
Patent number
US05659062

Reaction notes

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