Hydrochloric Acid → HCID 57480419, compound

HRID 2258297Notes

Reaction equation

HRID 2258297 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][C:10](=[O:47])[C@H:11]([CH:44]([CH3:46])[CH3:45])[CH2:12][C@H:13]([OH:43])[C@@H:14]([NH:35]C(OC(C)(C)C)=O)[CH2:15][C@H:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH2:30][CH2:31][CH2:32][O:33][CH3:34])[CH:22]=2)[CH:17]([CH3:19])[CH3:18])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:48]>O1CCOCC1>[ClH:48].[ClH:48].[N:1]1([CH2:7][CH2:8][NH:9][C:10](=[O:47])[C@H:11]([CH:44]([CH3:46])[CH3:45])[CH2:12][C@H:13]([OH:43])[C@@H:14]([NH2:35])[CH2:15][C@H:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH2:30][CH2:31][CH2:32][O:33][CH3:34])[CH:22]=2)[CH:17]([CH3:18])[CH3:19])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23625188HCID 23625188, compound

Product 1

HCID 57480419HCID 57480419, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.09 g of 5(S)-(tert-butoxycarbonyl)amino-4(S)-hydroxy-2(S)-isopropyl-7(S)-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid N-(2-morpholin-4-yl-ethyl)amide are dissolved in 4N hydrochloric acid in dioxane (40 ml) at 0° C. and stirred at that temperature for 2 hours. The reaction mixture is lyophilized and the title compound is obtained: Rf (dichloromethane/methanol 8:2)=0.27; HPLC Rt =9.52 min; FAB-MS (M+H)+ =566.

Sources & evidence

ORD record
ord-f56a1c3f458f442bbaf33834aba712a4
Source dataset
uspto-grants-1997_08
Patent number
US05659065

Reaction notes

Loading…