反应详情

温度

100 °C

12 g (60 mmol) of dimethyl pyridine-2,5-dicarboxylate were suspended in 30 ml of glacial acetic acid, and after that 13 ml of hydrogen peroxide (35%) were added at and while stirring. The mixture was then heated to 100° C. (internal temperature), while stirring, with a clear solution being formed at 50° C. After the mixture had been stirred at 100° C. for 90 minutes, it was allowed to cool down to 20° C. and the crystalline precipitate was filtered off with suction and washed with water; after drying, 7.5 g of product were obtained, m.p. 160° C. (decomp.).

1. stirringwhile stirring, with a clear solution
2. custombeing formed at 50° C
3. stirringAfter the mixture had been stirred at 100° C. for 90 minutes
4. temperatureto cool down to 20° C.
5. filtrationthe crystalline precipitate was filtered off with suction
6. washwashed with water
7. customafter drying