HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4,7,10-Tetraazacyclododecane → N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4,7,10-Tetraazacyclododecane | HCID 64963 | — |
| Reactant | 3-[(2-Chloroacetyl)amino]-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid | HCID 22921389 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide | HCID 22921399 | 75% |
Reaction Steps
According to the procedure described in Example 3, 105.8 g of 1,4,7,10-tetraazacyclododecane (0.62 mol) in 600 ml of CH3CN are added to a suspension of 40 g of 3-[(2-chloro-1-oxoethyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (prepared as described in Example 1) (0.62 mol) in 500 ml of CH3CN. 35.8 g of N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide (0.046 mol) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05660814 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-6bf0101ca62045d2ab6efd03097a4757 |
| Source note | uspto-grants-1997_08 |