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Bromoacetic Acid → 3-[[6-[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromoacetic Acid | HCID 6227 | — |
| 反応物 | N-(3-carboxy-2,4,6-triiodophenyl)-1,4,7,10-tetraazacyclododecane-1-acetamide | HCID 22921403 | — |
| 反応物 | 3-[[1-Oxo-6-[[(1,4,7,10-tetraazacyclododec-1-yl) acetyl]amino]hexyl]amino]-2,4,6-triiodobenzoic acid trihydrochloride | HCID 86751179 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[[6-[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acid | HCID 10558411 | 73.5% |
反応手順
According to the procedure described in Example 3, 142.4 g of compound (B) 3-[[1-oxo-6-[[(1,4,7,10-tetraazacyclododec-1-yl) acetyl]amino]hexyl]amino]-2,4,6-triiodobenzoic acid trihydrochloride (0.15 mol ) are reacted with 83.4 g of bromoacetic acid (0.60 mol) in 750 ml of 96% EtOH and 250 ml of H2O. 72.7 g of 3-[[6-[[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acid (0.072 mol) are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05660814 |
| 出典データセット | uspto-grants-1997_08 |
| ORD ID | ord-c9f6f4e4119f4578a3a7b4104f57b12f |
| 出典メモ | uspto-grants-1997_08 |