HRID2258398

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID64963

Cyclen

C8H20N4

结构：CCC(Cc1c(I)cc(I)c(NC(=O)CCCCCNC(=O)CCl)c1I)C(=O)O

HCID22921401

未命名化合物

PRODUCTS

生成物

结构：CCC(Cc1c(I)cc(I)c(NC(=O)CCCCCNC(=O)CN2CCNCCNCCNCC2)c1I)C(=O)O

HCID22921393

未命名化合物

收率 59%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31374

Dimethylacetamide

C4H9NO

2 次

PROCEDURE

实验过程

According to the procedure described in Example 5, 171.3 g of 1,4,7,10-tetraazacyclododecane (1,00 mol) in 500 ml of DMA are reacted with 190 g of 3-[[6-[(chloroacetyl) amino]-1-oxohexyl]amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (prepared according to the procedure described in Example 2) (0,25 mol) in 250 ml of DMA. 155 g of α-ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid (0.147 mol) are obtained.

WORKUP

后处理

customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d3a29fcf993e497388fdefede7c9e7bc
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05660814
来源说明: uspto-grants-1997_08

反应 SMILES

[NH:1]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:14][C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([NH:25][C:26]1[C:27]([I:41])=[C:28]([CH2:34][CH:35]([CH2:39][CH3:40])[C:36]([OH:38])=[O:37])[C:29]([I:33])=[CH:30][C:31]=1[I:32])=[O:24])=[O:16]>CC(N(C)C)=O>[CH2:39]([CH:35]([CH2:34][C:28]1[C:29]([I:33])=[CH:30][C:31]([I:32])=[C:26]([NH:25][C:23](=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][NH:17][C:15](=[O:16])[CH2:14][N:1]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[C:27]=1[I:41])[C:36]([OH:38])=[O:37])[CH3:40]