Bromoacetic Acid → alpha-Ethyl-2,4,6-triiodo-3-[[1-oxo-6-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-ylacetyl]amino]hexyl]amino]benzenepropanoic acid
Reaktionsgleichung
[CH2:1]([CH:3]([CH2:7][C:8]1[C:13]([I:14])=[CH:12][C:11]([I:15])=[C:10]([NH:16][C:17](=[O:39])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:38])[CH2:25][N:26]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33][NH:32][CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[C:9]=1[I:40])[C:4]([OH:6])=[O:5])[CH3:2].Br[CH2:42][C:43]([OH:45])=[O:44]>CCO>[CH2:1]([CH:3]([CH2:7][C:8]1[C:13]([I:14])=[CH:12][C:11]([I:15])=[C:10]([NH:16][C:17](=[O:39])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:38])[CH2:25][N:26]2[CH2:27][CH2:28][N:29]([CH2:42][C:43]([OH:45])=[O:44])[CH2:30][CH2:31][N:32]([CH2:42][C:43]([OH:45])=[O:44])[CH2:33][CH2:34][N:35]([CH2:3][C:4]([OH:6])=[O:5])[CH2:36][CH2:37]2)[C:9]=1[I:40])[C:4]([OH:6])=[O:5])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
According to the procedure described in Example 2, 111 g of compound (A) α-ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid (0.12 mol) are reacted with 67.2 g of bromoacetic acid (0.48 mol) in 600 ml of 80% EtOH. 63 g of α-ethyl-2,4,6-triiodo-3-[[1-oxo-6-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-ylacetyl]amino]hexyl]amino]benzenepropanoic acid (0.058 mol) are obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-2abe461f539c4104a39f140281856df9
- Quelldatensatz
- uspto-grants-1997_08
- Patentnummer
- US05660814
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