反应详情

To a solution of N,1-dimethyl-1H-indazole-3-carboxamide (3.42 g, 18 mmole) in dry THF (90 mL) was added a solution of LiAlH4 in THF (1.0 M, 36 mL, 36 mmole) slowly at RT. After 2 hr the mixture was heated to a gentle reflux. After 4 hr the mixture was cooled to RT and quenched by dropwise addition of 2.0 M NaOH until a white solid had formed. The mixture was dried (MgSO4), filtered, and concentrated under reduced pressure to give the title compound (3.28 g, 100%) as an oil which was sufficiently pure for use in the next step: MS (ES) m/e 176 (M+H)+.

1. temperatureAfter 2 hr the mixture was heated to a gentle reflux
2. customquenched by dropwise addition of 2.0 M NaOH until a white solid
3. customhad formed
4. dry with materialThe mixture was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure