反应详情

Thiomorpholine (6 ml, 59.7 mmol) was added to a dimethylformamide solution (30 ml) of 4-(5-chloropentylamino)-7-ethylamino-6-nitroquinazoline (2.50 g, 7.41 mmol) obtained in Reference Example 66 and the mixture was heated under reflux for 3 hours. After the solvent was distilled off, the residue was purified by silica gel column chromatography (chloroform:methanol=30:1) to give the title compound (2.95 g, 98.7%).

1. customobtained in Reference Example 66
2. temperaturethe mixture was heated
3. temperatureunder reflux for 3 hours
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by silica gel column chromatography (chloroform:methanol=30:1)