8-chloro-N-[4-(4-pyridinyl)butyl]dibenz[b,f][1,4]oxazepine-10(11H)-carboxamide → 8-chloro-N-[4-(4-pyridinyl)butyl]dibenz[b,f][1,4]oxazepine-10(11H)-carboxamide, hydrochloride

HRID 2258450Notes

Reaction equation

HRID 2258450 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[O:6][C:7]3[CH:27]=[CH:26][CH:25]=[CH:24][C:8]=3[CH2:9][N:10]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)=[O:12])[C:4]=2[CH:3]=1.Cl.CO>CO>[ClH:1].[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[O:6][C:7]3[CH:27]=[CH:26][CH:25]=[CH:24][C:8]=3[CH2:9][N:10]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)=[O:12])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 98015398-chloro-N-[4-(4-pyridinyl)butyl]dibenz[b,f][1,4]oxazepine-10(11H)-carboxamideHCID 21893726Hydrochloride methanol

Product 1

HCID 1317201338-chloro-N-[4-(4-pyridinyl)butyl]dibenz[b,f][1,4]oxazepine-10(11H)-carboxamide, hydrochlorideYield 56.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By the method described in Example 16, the title compound of Example 24 (0.82 g, 2.0 mmol) in 40 mL of MeOH was treated with 2N HCl/MeOH (5 mL) to produce 0.25 g of the title product.

Sources & evidence

ORD record
ord-a483e195d5794c35a0ba19673b1a12c1
Source dataset
uspto-grants-1997_08
Patent number
US05661146

Reaction notes

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