4-(Pyridin-4-yl)butan-1-amine → 8-chloro-N-[4-(4-pyridinyl)butyl]dibenzo[b,f][1,4]thiazepine-10(11H)-carboxamide, monohydrochloride

HRID 2258456Notes

Reaction equation

HRID 2258456 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[N:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][CH2:29][NH2:30])=[CH:22][CH:21]=1>>[ClH:1].[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([NH:30][CH2:29][CH2:28][CH2:27][CH2:26][C:23]3[CH:22]=[CH:21][N:20]=[CH:25][CH:24]=3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 135575324-(Pyridin-4-yl)butan-1-amineHCID 229217168-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

Product 1

HCID 1317190858-chloro-N-[4-(4-pyridinyl)butyl]dibenzo[b,f][1,4]thiazepine-10(11H)-carboxamide, monohydrochloride

Procedure

The title compound of Example 49 is reacted with the product of Example 23 by the method described in Example 18 to produce the free base of the title product. This material is converted to the title compound by the method described in Example 16.

Sources & evidence

ORD record
ord-30293482348f474487eb2f0bc78a5677
Source dataset
uspto-grants-1997_08
Patent number
US05661146

Reaction notes

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