反应详情

5,6-Dimethoxy-1(1-trityl-4-imidazolyl)methyl-1H -indazole-3-methanol (180.0 g), which had been ground in a mortar, was suspended in dichloromethane (1700 ml) at room temperature and then cooled with ice/water. Next, thionyl chloride (48.6 ml) was dropped thereinto within 5 minutes. The reaction mixture was poured into a saturated aqueous solution of sodium bicarbonate (2000 ml) and extracted with chloroform (5000 ml). After drying over sodium sulfate, filtering and evaporating under reduced pressure, a colorless solid was obtained (165.1 g). This solid product was used in the subsequent reaction without purification.

1. extractionextracted with chloroform (5000 ml)
2. dry with materialAfter drying over sodium sulfate
3. filtrationfiltering
4. customevaporating under reduced pressure
5. customa colorless solid was obtained (165.1 g)
6. customThis solid product was used in the subsequent reaction without purification